So glad you stopped by.
We develop and deploy molecular tools to systematically uncover new therapeutic opportunities in human health.
The Najm Lab is focused on harnessing the human genome in new and powerful ways. We develop next-generation genome engineering tools to identify the regulatory sequences that control genes, shape cell states, and drive disease. Our work aims to bridge a major gap in modern biology: moving from maps of the genome to a mechanistic understanding of how regulatory DNA operates.
By integrating CRISPR technologies, base editing, high-throughput screening, and computational modeling, we study gene regulation at unprecedented scale and resolution. We are particularly interested in defining how single bases may work individually or in combination to control cellular programs. Ultimately, we seek to transform these insights into new strategies for understanding disease biology and discovering therapeutic opportunities.
