Multi-locus CRISPRi targeting with a single truncated guide RNA
bioRxiv | 2023
Molly M Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Yanjing Liu, Nauman Javed, Jason D Buenrostro, Charles B Epstein, Eugenio Mattei, John G Doench, Bradley E Bernstein, Noam Shoresh, Fadi J Najm
Cell Genomics | 2023
Samantha M Bevill, Salvador Casaní-Galdón, Chadi A El Farran, Eli G Cytrynbaum, Kevin A Macias, Sylvie E Oldeman, Kayla J Oliveira, Molly M. Moore, Esmat Hegazi, Carmen Adriaens, Fadi J Najm, George D Demetri, Sonia Cohen, John T Mullen, Nicolò Riggi, Sarah E Johnstone, Bradley E Bernstein
Integrative dissection of gene regulatory elements at base resolution
Cell Genomics | 2023
Zeyu Chen, Nauman Javed, Molly Moore, Jingyi Wu, Gary Sun, Michael Vinyard, Alejandro Collins, Luca Pinello, Fadi J Najm*, Bradley E Bernstein*
Chromatin complex dependencies reveal targeting opportunities in leukemia
Nature Communications | 2023
Fadi J Najm, Peter DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, Amanda L Waterbury, Brian B Liau, Peter van Galen, John G Doench Bradley E Bernstein
Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements
Nature Genetics | 2022
Sofia Battaglia, Kevin Dong, Jingyi Wu, Zeyu Chen, Fadi J Najm, Yuanyuan Zhang, Molly M Moore, Vivian Hecht, Noam Shoresh, Bradley E Bernstein
Renewing your HBO1 subscription
Blood | 2022
Fadi J Najm and Peter van Galen
Cell type-specific intralocus interactions reveal oligodendrocyte mechanisms in MS
Cell | 2020
Daniel C Factor, Anna M Barbeau, Kevin C Allan, Lucille R Hu, Mayur Madhavan, An T Hoang, Kathryn EA Hazel, Parker A Hall, Sagar Nisraiyya, Fadi J Najm, Tyler E Miller, Zachary S Nevin, Robert T Karl, Bruna R Lima, Yanwei Song, Alexandra G Sibert, Gursimran K Dhillon, Christina Volsko, Cynthia F Bartels, Drew J Adams, Ranjan Dutta, Michael D Gallagher, William Phu, Alexey Kozlenkov, Stella Dracheva, Peter C Scacheri, Paul J Tesar, Olivia Corradin
Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP
Cell Chemical Biology | 2019
Dharmaraja Allimuthu, Zita Hubler, Fadi J Najm, Hong Tang, Ilya Bederman, William Seibel, Paul J Tesar, Drew J Adams
Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens
Nature Biotechnology | 2017
Fadi J Najm, Christine Strand, Katherine F Donovan, Mudra Hegde, Kendall R Sanson, Emma W Vaimberg, Meagan E Sullender, Ella Hartenian, Zohra Kalani, Nicolo Fusi, Jennifer Listgarten, Scott T Younger, Bradley E Bernstein, David E Root, John G Doench
Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance
Cell Stem Cell | 2017
Brian B Liau, Cem Sievers, Laura K Donohue, Shawn M Gillespie, William A Flavahan, Tyler E Miller, Andrew S Venteicher, Christine H Hebert, Christopher D Carey, Scott J Rodig, Sarah J Shareef, Fadi J Najm, Peter van Galen, Hiroaki Wakimoto, Daniel P Cahill, Jeremy N Rich, Jon C Aster, Mario L Suvà, Anoop P Patel, Bradley E Bernstein
Reprogramming of Mouse Fibroblasts to Induced Oligodendrocyte Progenitor Cells
Stem Cell Technologies in Neuroscience | 2017
Robert T Karl, Angela M Lager, Fadi J Najm, Paul J Tesar
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo
Nature | 2015
Fadi J Najm, Mayur Madhavan, Anita Zaremba, Elizabeth Shick, Robert T Karl, Daniel C Factor, Tyler E Miller, Zachary S Nevin, Christopher Kantor, Alex Sargent, Kevin L Quick, Daniela M Schlatzer, Hong Tang, Ruben Papoian, Kyle R Brimacombe, Min Shen, Matthew B Boxer, Ajit Jadhav, Andrew P Robinson, Joseph R Podojil, Stephen D Miller, Robert H Miller, Paul J Tesar
Nature Biotechnology | 2013
Fadi J Najm, Angela M Lager, Anita Zaremba, Krysta Wyatt, Andrew V Caprariello, Daniel C Factor, Robert T Karl, Tadao Maeda, Robert H Miller, Paul J Tesar
Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos
Epiblast Stem Cells: Methods and Protocols | 2013
Daniel C Factor, Fadi J Najm, Paul J Tesar
Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells
Nature Methods | 2011
Fadi J Najm, Anita Zaremba, Andrew V Caprariello, Shreya Nayak, Eric C Freundt, Peter C Scacheri, Robert H Miller, Paul J Tesar
Isolation of epiblast stem cells from preimplantation mouse embryos
Cell Stem Cell | 2011
Fadi J Najm, Josh G Chenoweth, Philip D Anderson, Joseph H Nadeau, Raymond W Redline, Ronald DG McKay, Paul J Tesar
