Chromatin complex dependencies reveal targeting opportunities in leukemia
Nature Communications | 2023
Fadi J. Najm, Peter DeWeirdt, Molly M. Moore, Samantha M. Bevill, Chadi A. El Farran, Kevin A. Macias, Mudra Hegde, Amanda L. Waterbury, Brian B. Liau, Peter van Galen, John G. Doench Bradley E. Bernstein
Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements
Nature Genetics | 2022
Sofia Battaglia, Kevin Dong, Jingyi Wu, Zeyu Chen, Fadi J Najm, Yuanyuan Zhang, Molly M Moore, Vivian Hecht, Noam Shoresh, Bradley E Bernstein
Renewing your HBO1 subscription
Blood | 2022
Fadi J Najm and Peter van Galen
Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens
Nature Biotechnology | 2018
Fadi J Najm, Christine Strand, Katherine F Donovan, Mudra Hegde, Kendall R Sanson, Emma W Vaimberg, Meagan E Sullender, Ella Hartenian, Zohra Kalani, Nicolo Fusi, Jennifer Listgarten, Scott T Younger, Bradley E Bernstein, David E Root, John G Doench
Cell type-specific intralocus interactions reveal oligodendrocyte mechanisms in MS
Cell | 2020
Daniel C Factor, Anna M Barbeau, Kevin C Allan, Lucille R Hu, Mayur Madhavan, An T Hoang, Kathryn EA Hazel, Parker A Hall, Sagar Nisraiyya, Fadi J Najm, Tyler E Miller, Zachary S Nevin, Robert T Karl, Bruna R Lima, Yanwei Song, Alexandra G Sibert, Gursimran K Dhillon, Christina Volsko, Cynthia F Bartels, Drew J Adams, Ranjan Dutta, Michael D Gallagher, William Phu, Alexey Kozlenkov, Stella Dracheva, Peter C Scacheri, Paul J Tesar, Olivia Corradin
Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP
Cell Chemical Biology | 2019
Dharmaraja Allimuthu, Zita Hubler, Fadi J Najm, Hong Tang, Ilya Bederman, William Seibel, Paul J Tesar, Drew J Adams
Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance
Cell Stem Cell | 2017
Brian B Liau, Cem Sievers, Laura K Donohue, Shawn M Gillespie, William A Flavahan, Tyler E Miller, Andrew S Venteicher, Christine H Hebert, Christopher D Carey, Scott J Rodig, Sarah J Shareef, Fadi J Najm, Peter van Galen, Hiroaki Wakimoto, Daniel P Cahill, Jeremy N Rich, Jon C Aster, Mario L Suvà, Anoop P Patel, Bradley E Bernstein
Reprogramming of Mouse Fibroblasts to Induced Oligodendrocyte Progenitor Cells
Stem Cell Technologies in Neuroscience | 2017
Robert T Karl, Angela M Lager, Fadi J Najm, Paul J Tesar
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo
Nature | 2015
Fadi J Najm, Mayur Madhavan, Anita Zaremba, Elizabeth Shick, Robert T Karl, Daniel C Factor, Tyler E Miller, Zachary S Nevin, Christopher Kantor, Alex Sargent, Kevin L Quick, Daniela M Schlatzer, Hong Tang, Ruben Papoian, Kyle R Brimacombe, Min Shen, Matthew B Boxer, Ajit Jadhav, Andrew P Robinson, Joseph R Podojil, Stephen D Miller, Robert H Miller, Paul J Tesar
Nature Biotechnology | 2013
Fadi J Najm, Angela M Lager, Anita Zaremba, Krysta Wyatt, Andrew V Caprariello, Daniel C Factor, Robert T Karl, Tadao Maeda, Robert H Miller, Paul J Tesar
Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos
Epiblast Stem Cells: Methods and Protocols | 2013
Daniel C Factor, Fadi J Najm, Paul J Tesar
Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells
Nature Methods | 2011
Fadi J Najm, Anita Zaremba, Andrew V Caprariello, Shreya Nayak, Eric C Freundt, Peter C Scacheri, Robert H Miller, Paul J Tesar
Isolation of epiblast stem cells from preimplantation mouse embryos
Cell Stem Cell | 2011
Fadi J Najm, Josh G Chenoweth, Philip D Anderson, Joseph H Nadeau, Raymond W Redline, Ronald DG McKay, Paul J Tesar