{"id":34,"date":"2022-02-21T01:30:19","date_gmt":"2022-02-21T01:30:19","guid":{"rendered":"https:\/\/najmlab.org\/?page_id=34"},"modified":"2025-02-05T17:54:26","modified_gmt":"2025-02-05T17:54:26","slug":"publications","status":"publish","type":"page","link":"https:\/\/najmlab.org\/?page_id=34","title":{"rendered":"publications"},"content":{"rendered":"\n

Multi-locus CRISPRi targeting with a single truncated guide RNA<\/a><\/p>\n\n\n\n

Nature Communications | 2025<\/strong><\/p>\n\n\n\n

Molly M Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J Cruz, Yanjing Liu, Nauman Javed, Salvador Casan\u00ed-Gald\u00f3n, Jason D Buenrostro, Charles B Epstein, Eugenio Mattei, John G Doench, Bradley E Bernstein, Noam Shoresh, Fadi J Najm<\/p>\n\n\n

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Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma<\/a><\/p>\n\n\n\n

Cell Genomics | 2023<\/strong><\/p>\n\n\n\n

Samantha M Bevill, Salvador Casan\u00ed-Gald\u00f3n, Chadi A El Farran, Eli G Cytrynbaum, Kevin A Macias, Sylvie E Oldeman, Kayla J Oliveira, Molly M. Moore, Esmat Hegazi, Carmen Adriaens, Fadi J Najm, George D Demetri, Sonia Cohen, John T Mullen, Nicol\u00f2 Riggi, Sarah E Johnstone, Bradley E Bernstein<\/p>\n\n\n\n

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Integrative dissection of gene regulatory elements at base resolution<\/a><\/p>\n\n\n\n

Cell Genomics | 2023<\/strong><\/p>\n\n\n\n

Zeyu Chen, Nauman Javed, Molly Moore, Jingyi Wu, Gary Sun, Michael Vinyard, Alejandro Collins, Luca Pinello, Fadi J Najm*, Bradley E Bernstein*<\/p>\n\n\n\n

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Chromatin complex dependencies reveal targeting opportunities in leukemia<\/a><\/p>\n\n\n\n

Nature Communications | 2023<\/strong><\/p>\n\n\n\n

Fadi J Najm, Peter DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, Amanda L Waterbury, Brian B Liau, Peter van Galen, John G Doench Bradley E Bernstein<\/p>\n\n\n\n

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Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements<\/a><\/p>\n\n\n\n

Nature Genetics | 2022<\/strong><\/p>\n\n\n\n

Sofia Battaglia, Kevin Dong, Jingyi Wu, Zeyu Chen, Fadi J Najm, Yuanyuan Zhang, Molly M Moore, Vivian Hecht, Noam Shoresh, Bradley E Bernstein<\/p>\n\n\n\n

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Renewing your HBO1 subscription<\/a><\/p>\n\n\n\n

Blood<\/strong> | 2022<\/strong><\/p>\n\n\n\n

Fadi J Najm and Peter van Galen<\/p>\n\n\n\n

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Cell type-specific intralocus interactions reveal oligodendrocyte mechanisms in MS<\/a><\/p>\n\n\n\n

Cell<\/strong> | 2020<\/strong><\/p>\n\n\n\n

Daniel C Factor, Anna M Barbeau, Kevin C Allan, Lucille R Hu, Mayur Madhavan, An T Hoang, Kathryn EA Hazel, Parker A Hall, Sagar Nisraiyya, Fadi J Najm, Tyler E Miller, Zachary S Nevin, Robert T Karl, Bruna R Lima, Yanwei Song, Alexandra G Sibert, Gursimran K Dhillon, Christina Volsko, Cynthia F Bartels, Drew J Adams, Ranjan Dutta, Michael D Gallagher, William Phu, Alexey Kozlenkov, Stella Dracheva, Peter C Scacheri, Paul J Tesar, Olivia Corradin<\/p>\n\n\n\n

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Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP<\/a><\/p>\n\n\n\n

Cell Chemical Biology<\/strong> | 2019<\/strong><\/p>\n\n\n\n

Dharmaraja Allimuthu, Zita Hubler, Fadi J Najm, Hong Tang, Ilya Bederman, William Seibel, Paul J Tesar, Drew J Adams <\/p>\n\n\n\n

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Orthologous CRISPR\u2013Cas9 enzymes for combinatorial genetic screens<\/a><\/p>\n\n\n\n

Nature Biotechnology | 2017<\/strong><\/p>\n\n\n\n

Fadi J Najm, Christine Strand, Katherine F Donovan, Mudra Hegde, Kendall R Sanson, Emma W Vaimberg, Meagan E Sullender, Ella Hartenian, Zohra Kalani, Nicolo Fusi, Jennifer Listgarten, Scott T Younger, Bradley E Bernstein, David E Root, John G Doench<\/p>\n\n\n\n

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Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance<\/a><\/p>\n\n\n\n

Cell Stem Cell | 2017<\/strong><\/p>\n\n\n\n

Brian B Liau, Cem Sievers, Laura K Donohue, Shawn M Gillespie, William A Flavahan, Tyler E Miller, Andrew S Venteicher, Christine H Hebert, Christopher D Carey, Scott J Rodig, Sarah J Shareef, Fadi J Najm, Peter van Galen, Hiroaki Wakimoto, Daniel P Cahill, Jeremy N Rich, Jon C Aster, Mario L Suv\u00e0, Anoop P Patel, Bradley E Bernstein<\/p>\n\n\n\n

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Reprogramming of Mouse Fibroblasts to Induced Oligodendrocyte Progenitor Cells<\/a><\/p>\n\n\n\n

Stem Cell Technologies in Neuroscience | 2017<\/strong><\/p>\n\n\n\n

Robert T Karl, Angela M Lager, Fadi J Najm, Paul J Tesar<\/p>\n\n\n\n

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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo<\/a><\/p>\n\n\n\n

Nature | 2015<\/strong><\/p>\n\n\n\n

Fadi J Najm, Mayur Madhavan, Anita Zaremba, Elizabeth Shick, Robert T Karl, Daniel C Factor, Tyler E Miller, Zachary S Nevin, Christopher Kantor, Alex Sargent, Kevin L Quick, Daniela M Schlatzer, Hong Tang, Ruben Papoian, Kyle R Brimacombe, Min Shen, Matthew B Boxer, Ajit Jadhav, Andrew P Robinson, Joseph R Podojil, Stephen D Miller, Robert H Miller, Paul J Tesar<\/p>\n\n\n\n

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Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells<\/a><\/p>\n\n\n\n

Nature Biotechnology | 2013<\/strong><\/p>\n\n\n\n

Fadi J Najm, Angela M Lager, Anita Zaremba, Krysta Wyatt, Andrew V Caprariello, Daniel C Factor, Robert T Karl, Tadao Maeda, Robert H Miller, Paul J Tesar<\/p>\n\n\n\n

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Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos<\/a><\/p>\n\n\n\n

Epiblast Stem Cells: Methods and Protocols<\/strong> | 2013<\/strong><\/p>\n\n\n\n

Daniel C Factor, Fadi J Najm, Paul J Tesar<\/p>\n\n\n\n

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Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells<\/a><\/p>\n\n\n\n

Nature Methods | 2011<\/strong><\/p>\n\n\n\n

Fadi J Najm, Anita Zaremba, Andrew V Caprariello, Shreya Nayak, Eric C Freundt, Peter C Scacheri, Robert H Miller, Paul J Tesar<\/p>\n\n\n\n

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Isolation of epiblast stem cells from preimplantation mouse embryos<\/a><\/p>\n\n\n\n

Cell Stem Cell<\/strong> | 2011<\/strong><\/p>\n\n\n\n

Fadi J Najm, Josh G Chenoweth, Philip D Anderson, Joseph H Nadeau, Raymond W Redline, Ronald DG McKay, Paul J Tesar<\/p>\n\n\n\n

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Multi-locus CRISPRi targeting with a single truncated guide RNA Nature Communications | 2025 Molly M Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J Cruz, Yanjing Liu, Nauman Javed, Salvador […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"class_list":["post-34","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/pages\/34","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/najmlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34"}],"version-history":[{"count":22,"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/pages\/34\/revisions"}],"predecessor-version":[{"id":499,"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/pages\/34\/revisions\/499"}],"wp:attachment":[{"href":"https:\/\/najmlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}