{"id":34,"date":"2022-02-21T01:30:19","date_gmt":"2022-02-21T01:30:19","guid":{"rendered":"https:\/\/najmlab.org\/?page_id=34"},"modified":"2026-09-03T14:45:30","modified_gmt":"2026-09-03T14:45:30","slug":"publications","status":"publish","type":"page","link":"https:\/\/najmlab.org\/?page_id=34","title":{"rendered":"publications"},"content":{"rendered":"\n

Bibliography<\/a><\/strong><\/p>\n\n\n\n

\n\n\n\n

Chromatin topology and distal elements underlie divergent cell-type-specific regulation of 9p21 locus cell cycle genes.<\/a><\/p>\n\n\n\n

Cell Genomics | 2026<\/strong><\/p>\n\n\n\n

Torlai Triglia E, Miller TE, Durand NC, Kim KL, Casan\u00ed-Gald\u00f3n S, D’Antonio J, Javed N, Paz Hernandez A, Raman A, Cruz AJ, Issner R, Choudhary A, Aguet F, Verga J, Chan M, Ramanathan V, Li CM, Hecht V, Hansen AS, Aryee MJ, Epstein CB, Kelley DR, Najm FJ, Shoresh N, Ardlie K, Hendrickson DG, Ruby JG, Bernstein BE, Gaskell E.<\/p>\n\n\n\n

\n\n\n\n

Synergistic targeting of eIF4A-mediated translation initiation and apoptosis in acute myeloid leukemia<\/a><\/p>\n\n\n\n

Blood Neoplasia | 2026<\/strong><\/p>\n\n\n\n

Lee YS, Good JD, Awais N, Eschle BK, Lineberry MS, Lin J, Wunderlich M, Thibodeau J, Edwards H, Teo JL, Bibeau S, Wollman M, Karadimov G, Sariipek N, Salik B, Acosta J, Noel J, Cucchi DGJ, DePasquale EAK, Gokhale PC, Ritz J, Ge Y, Miller PG, Najm FJ, Stone RM, Garcia JS, Lane AA, Jones CL, van Galen P<\/p>\n\n\n\n

\n\n\n\n

Multi-locus CRISPRi targeting with a single truncated guide RNA<\/a><\/p>\n\n\n\n

Nature Communications | 2025<\/strong><\/p>\n\n\n\n

Molly M Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J Cruz, Yanjing Liu, Nauman Javed, Salvador Casan\u00ed-Gald\u00f3n, Jason D Buenrostro, Charles B Epstein, Eugenio Mattei, John G Doench, Bradley E Bernstein, Noam Shoresh, Fadi J Najm<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n
\n\n\n\n

Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma<\/a><\/p>\n\n\n\n

Cell Genomics | 2023<\/strong><\/p>\n\n\n\n

Samantha M Bevill, Salvador Casan\u00ed-Gald\u00f3n, Chadi A El Farran, Eli G Cytrynbaum, Kevin A Macias, Sylvie E Oldeman, Kayla J Oliveira, Molly M. Moore, Esmat Hegazi, Carmen Adriaens, Fadi J Najm, George D Demetri, Sonia Cohen, John T Mullen, Nicol\u00f2 Riggi, Sarah E Johnstone, Bradley E Bernstein<\/p>\n\n\n\n

\n\n\n\n

Integrative dissection of gene regulatory elements at base resolution<\/a><\/p>\n\n\n\n

Cell Genomics | 2023<\/strong><\/p>\n\n\n\n

Zeyu Chen, Nauman Javed, Molly Moore, Jingyi Wu, Gary Sun, Michael Vinyard, Alejandro Collins, Luca Pinello, Fadi J Najm*, Bradley E Bernstein*<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\n\n\n\n

Chromatin complex dependencies reveal targeting opportunities in leukemia<\/a><\/p>\n\n\n\n

Nature Communications | 2023<\/strong><\/p>\n\n\n\n

Fadi J Najm, Peter DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, Amanda L Waterbury, Brian B Liau, Peter van Galen, John G Doench Bradley E Bernstein<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\n\n\n\n

Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements<\/a><\/p>\n\n\n\n

Nature Genetics | 2022<\/strong><\/p>\n\n\n\n

Sofia Battaglia, Kevin Dong, Jingyi Wu, Zeyu Chen, Fadi J Najm, Yuanyuan Zhang, Molly M Moore, Vivian Hecht, Noam Shoresh, Bradley E Bernstein<\/p>\n\n\n\n

\n\n\n\n

Renewing your HBO1 subscription<\/a><\/p>\n\n\n\n

Blood<\/strong> | 2022<\/strong><\/p>\n\n\n\n

Fadi J Najm and Peter van Galen<\/p>\n\n\n\n

\n\n\n\n

Cell type-specific intralocus interactions reveal oligodendrocyte mechanisms in MS<\/a><\/p>\n\n\n\n

Cell<\/strong> | 2020<\/strong><\/p>\n\n\n\n

Daniel C Factor, Anna M Barbeau, Kevin C Allan, Lucille R Hu, Mayur Madhavan, An T Hoang, Kathryn EA Hazel, Parker A Hall, Sagar Nisraiyya, Fadi J Najm, Tyler E Miller, Zachary S Nevin, Robert T Karl, Bruna R Lima, Yanwei Song, Alexandra G Sibert, Gursimran K Dhillon, Christina Volsko, Cynthia F Bartels, Drew J Adams, Ranjan Dutta, Michael D Gallagher, William Phu, Alexey Kozlenkov, Stella Dracheva, Peter C Scacheri, Paul J Tesar, Olivia Corradin<\/p>\n\n\n\n

\n\n\n\n

Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP<\/a><\/p>\n\n\n\n

Cell Chemical Biology<\/strong> | 2019<\/strong><\/p>\n\n\n\n

Dharmaraja Allimuthu, Zita Hubler, Fadi J Najm, Hong Tang, Ilya Bederman, William Seibel, Paul J Tesar, Drew J Adams <\/p>\n\n\n\n

\n\n\n\n

Orthologous CRISPR\u2013Cas9 enzymes for combinatorial genetic screens<\/a><\/p>\n\n\n\n

Nature Biotechnology | 2017<\/strong><\/p>\n\n\n\n

Fadi J Najm, Christine Strand, Katherine F Donovan, Mudra Hegde, Kendall R Sanson, Emma W Vaimberg, Meagan E Sullender, Ella Hartenian, Zohra Kalani, Nicolo Fusi, Jennifer Listgarten, Scott T Younger, Bradley E Bernstein, David E Root, John G Doench<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\n\n\n\n

Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance<\/a><\/p>\n\n\n\n

Cell Stem Cell | 2017<\/strong><\/p>\n\n\n\n

Brian B Liau, Cem Sievers, Laura K Donohue, Shawn M Gillespie, William A Flavahan, Tyler E Miller, Andrew S Venteicher, Christine H Hebert, Christopher D Carey, Scott J Rodig, Sarah J Shareef, Fadi J Najm, Peter van Galen, Hiroaki Wakimoto, Daniel P Cahill, Jeremy N Rich, Jon C Aster, Mario L Suv\u00e0, Anoop P Patel, Bradley E Bernstein<\/p>\n\n\n\n

\n\n\n\n

Reprogramming of Mouse Fibroblasts to Induced Oligodendrocyte Progenitor Cells<\/a><\/p>\n\n\n\n

Stem Cell Technologies in Neuroscience | 2017<\/strong><\/p>\n\n\n\n

Robert T Karl, Angela M Lager, Fadi J Najm, Paul J Tesar<\/p>\n\n\n\n

\n\n\n\n

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo<\/a><\/p>\n\n\n\n

Nature | 2015<\/strong><\/p>\n\n\n\n

Fadi J Najm, Mayur Madhavan, Anita Zaremba, Elizabeth Shick, Robert T Karl, Daniel C Factor, Tyler E Miller, Zachary S Nevin, Christopher Kantor, Alex Sargent, Kevin L Quick, Daniela M Schlatzer, Hong Tang, Ruben Papoian, Kyle R Brimacombe, Min Shen, Matthew B Boxer, Ajit Jadhav, Andrew P Robinson, Joseph R Podojil, Stephen D Miller, Robert H Miller, Paul J Tesar<\/p>\n\n\n\n

\n\n\n\n

Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells<\/a><\/p>\n\n\n\n

Nature Biotechnology | 2013<\/strong><\/p>\n\n\n\n

Fadi J Najm, Angela M Lager, Anita Zaremba, Krysta Wyatt, Andrew V Caprariello, Daniel C Factor, Robert T Karl, Tadao Maeda, Robert H Miller, Paul J Tesar<\/p>\n\n\n\n

\n\n\n\n

Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos<\/a><\/p>\n\n\n\n

Epiblast Stem Cells: Methods and Protocols<\/strong> | 2013<\/strong><\/p>\n\n\n\n

Daniel C Factor, Fadi J Najm, Paul J Tesar<\/p>\n\n\n\n

\n\n\n\n

Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells<\/a><\/p>\n\n\n\n

Nature Methods | 2011<\/strong><\/p>\n\n\n\n

Fadi J Najm, Anita Zaremba, Andrew V Caprariello, Shreya Nayak, Eric C Freundt, Peter C Scacheri, Robert H Miller, Paul J Tesar<\/p>\n\n\n\n

\n\n\n\n

Isolation of epiblast stem cells from preimplantation mouse embryos<\/a><\/p>\n\n\n\n

Cell Stem Cell<\/strong> | 2011<\/strong><\/p>\n\n\n\n

Fadi J Najm, Josh G Chenoweth, Philip D Anderson, Joseph H Nadeau, Raymond W Redline, Ronald DG McKay, Paul J Tesar<\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

Bibliography Chromatin topology and distal elements underlie divergent cell-type-specific regulation of 9p21 locus cell cycle genes. Cell Genomics | 2026 Torlai Triglia E, Miller TE, Durand NC, Kim KL, Casan\u00ed-Gald\u00f3n […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"class_list":["post-34","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/pages\/34","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/najmlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34"}],"version-history":[{"count":25,"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/pages\/34\/revisions"}],"predecessor-version":[{"id":579,"href":"https:\/\/najmlab.org\/index.php?rest_route=\/wp\/v2\/pages\/34\/revisions\/579"}],"wp:attachment":[{"href":"https:\/\/najmlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}